Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/79507
Title: INVESTIGATIONS ON THE ROLES OF CLASS 3 SEMAPHORINS IN THE ADULT HIPPOCAMPUS
Authors: TECLISE NG
Keywords: Semaphorins, Signaling, Neurogenesis, Hippocampus, Memory
Issue Date: 19-Mar-2014
Source: TECLISE NG (2014-03-19). INVESTIGATIONS ON THE ROLES OF CLASS 3 SEMAPHORINS IN THE ADULT HIPPOCAMPUS. ScholarBank@NUS Repository.
Abstract: Class 3 Semaphorins are important guidance cues for the development of the embryonic nervous system. However, the roles of Semaphorins in the adult nervous system have not been characterized. This study uncovered the novel roles of Class 3 Semaphorins in promoting dendritic growth via a Cdk5-FAK pathway and in regulating cell positioning of newborn neurons in the adult hippocampus via the GSK3ß pathway. In addition, Sema3F/NRP2 signaling in the adult dentate gyrus is critical for contextual fear learning. This study sets the stage for future investigations on how regulation of Class 3 Semaphorins contributes to brain functions in different physiological and pathological states and could imply potential clinical applications.
URI: http://scholarbank.nus.edu.sg/handle/10635/79507
Appears in Collections:Ph.D Theses (Open)

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
NgT.pdf3.4 MBAdobe PDF

OPEN

NoneView/Download

Page view(s)

60
checked on Feb 16, 2018

Download(s)

23
checked on Feb 16, 2018

Google ScholarTM

Check


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.