Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/79502
Title: INVESTIGATION OF THE TOXICITY OF SILVER AND GOLD NANOPARTICLES
Authors: WANG CHUNYAN
Keywords: nanomaterials, size-dependent, shape-dependent, capping agent-dependent, cytotoxicity, genotoxicity
Issue Date: 22-Aug-2013
Citation: WANG CHUNYAN (2013-08-22). INVESTIGATION OF THE TOXICITY OF SILVER AND GOLD NANOPARTICLES. ScholarBank@NUS Repository.
Abstract: Many nanomaterials have been synthesized and explored for potential use in consumer and medical products. The rapid increase of nanomaterial applications has attracted researchers¿ attention on their health and environmental safety concerns. This thesis focuses on investigation of the toxicity of silver and gold nanoparticles. In the first part, silver nanoparticles with natural material water extracts as functional groups were synthesized and their toxicity was investigated on human tumor cells. In the second part, the toxicity of silver and gold nanoparticles with different shapes was carefully examined. In the last part, the cytotoxicity and genotoxicity of silver and gold nanoparticles to human colon cancer stem cells and embryonic stem cells were explored. The results in this project demonstrate that the toxicity of nanomaterials is very sensitive, which could be influenced by the components, the surface group, the size, the shape and the colloidal stability of the nanomaterials.
URI: http://scholarbank.nus.edu.sg/handle/10635/79502
Appears in Collections:Ph.D Theses (Open)

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