Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/79381
Title: ESSENTIAL LIPIDS DETERMINE THE FORMATION OF CUBIC MEMBRANES DURING STARVATION: A FUNCTIONAL RELATIONSHIP TO AUTOPHAGY AND SURVIVAL?
Authors: CHONG KETPIN
Keywords: Cubic membranes, Autophagy, Survivability, Starvation, Mitochondria, ATP
Issue Date: 24-Jan-2014
Source: CHONG KETPIN (2014-01-24). ESSENTIAL LIPIDS DETERMINE THE FORMATION OF CUBIC MEMBRANES DURING STARVATION: A FUNCTIONAL RELATIONSHIP TO AUTOPHAGY AND SURVIVAL?. ScholarBank@NUS Repository.
Abstract: Cubic membranes (CM) are highly organized membrane structures found in biological systems that are frequently observed in cells under stress, disease states or viral infection. CM found in amoeba Chaos carolinense are to date the best characterized CM and the transformation of mitochondrial inner membranes from tubular to cubic organization in Chaos can be triggered simply by starvation. Here, I show that ?essential lipids? endowed Chaos? mitochondria with the ability to transform into CM. Interestingly, ether lipids; plasmalogen might have possible role(s) in membrane shaping to CM. I also demonstrated that the induction of autophagy and the appearance of CM are associated. Furthermore, cubic morphology in the mitochondria might have prevented their sequestration by autophagosomes, hence, slowing their rate of degradation during starvation. A sustained amount of ATP here might thus render greater survivability in Chaos for a longer period during starvation.
URI: http://scholarbank.nus.edu.sg/handle/10635/79381
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