Please use this identifier to cite or link to this item: https://doi.org/10.1186/gb-2012-13-10-R82
Title: BatMeth: improved mapper for bisulfite sequencing reads on DNA methylation
Authors: Lim, J.-Q.
Tennakoon, C.
Li, G.
Wong, E.
Ruan, Y.
Wei, C.-L.
Sung, W.-K. 
Issue Date: 10-Mar-2012
Source: Lim, J.-Q., Tennakoon, C., Li, G., Wong, E., Ruan, Y., Wei, C.-L., Sung, W.-K. (2012-03-10). BatMeth: improved mapper for bisulfite sequencing reads on DNA methylation. Genome Biology 13 (10) : -. ScholarBank@NUS Repository. https://doi.org/10.1186/gb-2012-13-10-R82
Abstract: DNA methylation plays a crucial role in higher organisms. Coupling bisulfite treatment with next generation sequencing enables the interrogation of 5-methylcytosine sites in the genome. However, bisulfite conversion introduces mismatches between the reads and the reference genome, which makes mapping of Illumina and SOLiD reads slow and inaccurate. BatMeth is an algorithm that integrates novel Mismatch Counting, List Filtering, Mismatch Stage Filtering and Fast Mapping onto Two Indexes components to improve unique mapping rate, speed and precision. Experimental results show that BatMeth is faster and more accurate than existing tools. BatMeth is freely available at http://code.google.com/p/batmeth/. © 2012 Lim et al.; licensee BioMed Central Ltd.
Source Title: Genome Biology
URI: http://scholarbank.nus.edu.sg/handle/10635/77828
ISSN: 1474760X
DOI: 10.1186/gb-2012-13-10-R82
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
2012-batmeth_improved_mapper_bisulfite-published.pdf2.86 MBAdobe PDF

OPEN

PublishedView/Download

SCOPUSTM   
Citations

25
checked on Feb 26, 2018

WEB OF SCIENCETM
Citations

19
checked on Feb 26, 2018

Page view(s)

53
checked on Feb 25, 2018

Download(s)

2
checked on Feb 25, 2018

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.