Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/77768
Title: Lipidomics-Based Analysis in Magnaporthe Oryzae
Authors: XUE YANGKUI
Keywords: magnaporthe,lipidomics,lipids,turgor,TAG
Issue Date: 26-Sep-2013
Source: XUE YANGKUI (2013-09-26). Lipidomics-Based Analysis in Magnaporthe Oryzae. ScholarBank@NUS Repository.
Abstract: Magnaporthe oryzae (M. oryzae) is the causal agent of the rice blast disease. Triacylglycerides (TAGs) were one of the major sources used to generate turgor pressure as a means for M. oryzae to penetrate into host?s leaf. Lipids therefore play a very important role in the pathogenesis. However, there is up to date no lipidomics study of M. oryzae available. The lipidome of M. oryzae was profiled and quantified along the pathological cycle. The lipidomics study as a platform was further used to analyze two beta oxidation pathway mutants and proposed possible explanation for their nonpathogenicity. Previous studies already discovered that trehalose synthase (Tps1) was not only responsible for the production of trehalose and utilization of nitrogen source, but also the regulation of several NADPH-dependent transcriptional corepressors, namely Nmr1, Nmr2, and Nmr3, which can each bind NADP. Therefore, the structure of Tps1 was modeled for screening of possible inhibitors in silico against a database of 400k compounds, and molecular dynamics studies were also done for some of the best hits. Advice was then given for future inhibitor design in the context of rice blast control.
URI: http://scholarbank.nus.edu.sg/handle/10635/77768
Appears in Collections:Ph.D Theses (Open)

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
cover page.pdf64.1 kBAdobe PDF

OPEN

NoneView/Download
Main Content.pdf17.65 MBAdobe PDF

OPEN

NoneView/Download
Content - front.pdf105.24 kBAdobe PDF

OPEN

NoneView/Download

Page view(s)

85
checked on Feb 24, 2018

Download(s)

328
checked on Feb 24, 2018

Google ScholarTM

Check


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.