Please use this identifier to cite or link to this item: https://doi.org/10.2174/138955706776073439
Title: Recent advances in the stereocontrolled synthesis of antisense phosphorothioates
Authors: Lu, Y. 
Keywords: Antisense strategy
Phosphoramidites
Phosphorothioate oligonucleotides
Stereocontrolled synthesis
Issue Date: Mar-2006
Citation: Lu, Y. (2006-03). Recent advances in the stereocontrolled synthesis of antisense phosphorothioates. Mini-Reviews in Medicinal Chemistry 6 (3) : 319-330. ScholarBank@NUS Repository. https://doi.org/10.2174/138955706776073439
Abstract: Antisense technology has advanced substantially in the past few decades and now is a well-established therapeutic approach in medicinal chemistry, and it may prove to be a valuable tool in the treatment of a wide range of diseases. Phosphorothioate oligonucleotides are among the most important and promising antisense agents. However, the key drawback lies in their polydiastereomerism, which manifests itself in the different chemical and biological properties of the diastereomeric species. Methodologies towards the stereocontrolled. synthesis of antisense phosphorothioate oligonucleotides have been well investigated in recent years. In this review, the progress in this field is summarized. © 2006 Bentham Science Publishers Ltd.
Source Title: Mini-Reviews in Medicinal Chemistry
URI: http://scholarbank.nus.edu.sg/handle/10635/77643
ISSN: 13895575
DOI: 10.2174/138955706776073439
Appears in Collections:Staff Publications

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