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Title: Phosphinegold(I) thiolates - Pharmacological use and potential
Authors: Tiekink, E.R.T. 
Keywords: Anti-tumour activity
Metal-based drugs
Rheumatoid arthritis
Issue Date: 2003
Source: Tiekink, E.R.T. (2003). Phosphinegold(I) thiolates - Pharmacological use and potential. Bioinorganic Chemistry and Applications 1 (1) : 53-67. ScholarBank@NUS Repository.
Abstract: A brief overview of the use of gold compounds in medicine, namely in the treatment of rheumatoid arthritis is presented, including that of the orally-administered triethylphosphinegold(I) tetraacetylatedthioglucose species, auranofin. A summary of an evaluation for anti-arthritic activity of novel phosphinegold(I) thiolate analogues containing biologically active thiols is given. This shows that compounds with greater efficacy and reduced toxic side-effects, at least in the in vivo model studied, can be developed. More recent investigations on this class of compound have focussed on their putative anti-tumour activity. Significant cytotoxicity and apparent cellular specificity have been discovered for certain phosphinegold(I) thiolates carrying water-solubilising groups. All indications are there that the continued exploration of the medicinal properties of phosphinegold(I) thiolates offers very real opportunities in metallotherapeutics.
Source Title: Bioinorganic Chemistry and Applications
ISSN: 15653633
Appears in Collections:Staff Publications

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