Please use this identifier to cite or link to this item:
|Title:||Phosphinegold(I) thiolates - Pharmacological use and potential|
|Source:||Tiekink, E.R.T. (2003). Phosphinegold(I) thiolates - Pharmacological use and potential. Bioinorganic Chemistry and Applications 1 (1) : 53-67. ScholarBank@NUS Repository.|
|Abstract:||A brief overview of the use of gold compounds in medicine, namely in the treatment of rheumatoid arthritis is presented, including that of the orally-administered triethylphosphinegold(I) tetraacetylatedthioglucose species, auranofin. A summary of an evaluation for anti-arthritic activity of novel phosphinegold(I) thiolate analogues containing biologically active thiols is given. This shows that compounds with greater efficacy and reduced toxic side-effects, at least in the in vivo model studied, can be developed. More recent investigations on this class of compound have focussed on their putative anti-tumour activity. Significant cytotoxicity and apparent cellular specificity have been discovered for certain phosphinegold(I) thiolates carrying water-solubilising groups. All indications are there that the continued exploration of the medicinal properties of phosphinegold(I) thiolates offers very real opportunities in metallotherapeutics.|
|Source Title:||Bioinorganic Chemistry and Applications|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Feb 22, 2018
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.