Please use this identifier to cite or link to this item: https://doi.org/10.3390/molecules14082959
Title: Chemical and biological characterization of oleanane triterpenoids from soy
Authors: Zhang, W.
Popovich, D.G. 
Keywords: Apoptosis
Glycine max
Hep-G2
MTT
Oleanane triterpenes
Soy
Issue Date: Aug-2009
Citation: Zhang, W., Popovich, D.G. (2009-08). Chemical and biological characterization of oleanane triterpenoids from soy. Molecules 14 (8) : 2959-2975. ScholarBank@NUS Repository. https://doi.org/10.3390/molecules14082959
Abstract: Soyasaponins are a group of complex and structural diverse oleanane triterpenoids found in soy (Glycine max) and other legumes. They are primarily classified into two main groups - group A and B - based on the attachment of sugar moieties at positions C-3 and C-22 of the ring structures. Group A soyasaponins are bidesmosidic, while group B soyasaponins are monodesmosidic. Group B soyasaponins are further classified into two subcategories known as 2,3-dihydro-2,5-dihydroxy-6 -methyl-4Hpyran- 4-one (DDMP) and non-DDMP conjugated molecules. The preparation and purification of soyasaponin molecules is complicated by the presence of bioactive soy isoflavones, which often overlap with soyasaponin in polarity and must removed from extracts before biological assessment. Soyasaponin extracts, aglycones of group A and B and individual group B soyasaponins such as soyasaponin I have been reported to posses specific bioactive properties, such as in vitro anti-cancer properties by modulating the cell cycle and inducing apoptosis. The isolation, chemical characterization and detection strategies by HPLC and HPLC-MS are reviewed, along with the reported bioactive effects of soyasaponin extracts and individual molecules in cultured cancer cell experiments. © 2009.
Source Title: Molecules
URI: http://scholarbank.nus.edu.sg/handle/10635/77586
ISSN: 14203049
DOI: 10.3390/molecules14082959
Appears in Collections:Staff Publications

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