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Title: Carbon nanotubes for delivery of small molecule drugs
Authors: Wong, B.S.
Yoong, S.L.
Jagusiak, A.
Panczyk, T.
Ho, H.K. 
Ang, W.H. 
Pastorin, G. 
Keywords: Anticancer drugs
Carbon nanotubes
Drug delivery
Non-anticancer drugs
Small molecule drugs
Issue Date: Dec-2013
Source: Wong, B.S., Yoong, S.L., Jagusiak, A., Panczyk, T., Ho, H.K., Ang, W.H., Pastorin, G. (2013-12). Carbon nanotubes for delivery of small molecule drugs. Advanced Drug Delivery Reviews 65 (15) : 1964-2015. ScholarBank@NUS Repository.
Abstract: In the realm of drug delivery, carbon nanotubes (CNTs) have gained tremendous attention as promising nanocarriers, owing to their distinct characteristics, such as high surface area, enhanced cellular uptake and the possibility to be easily conjugated with many therapeutics, including both small molecules and biologics, displaying superior efficacy, enhanced specificity and diminished side effects. While most CNT-based drug delivery system (DDS) had been engineered to combat cancers, there are also emerging reports that employ CNTs as either the main carrier or adjunct material for the delivery of various non-anticancer drugs.In this review, the delivery of small molecule drugs is expounded, with special attention paid to the current progress of in vitro and in vivo research involving CNT-based DDSs, before finally concluding with some consideration on inevitable complications that hamper successful disease intervention with CNTs. © 2013 Elsevier B.V.
Source Title: Advanced Drug Delivery Reviews
ISSN: 0169409X
DOI: 10.1016/j.addr.2013.08.005
Appears in Collections:Staff Publications

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