Please use this identifier to cite or link to this item:
|Title:||Anticancer platinum (IV) prodrugs with novel modes of activity|
|Keywords:||Activation by reduction|
|Citation:||Chin, C.F.,Wong, D.Y.Q.,Jothibasu, R.,Ang, W.H. (2011-11). Anticancer platinum (IV) prodrugs with novel modes of activity. Current Topics in Medicinal Chemistry 11 (21) : 2602-2612. ScholarBank@NUS Repository. https://doi.org/10.2174/156802611798040778|
|Abstract:||Over the past four decades, the search for improved platinum drugs based on the classical platinum(II)-diam(m)ine pharmacophore has yielded only a handful of successful candidates. New methodologies centred on platinum(IV) complexes, with better stability and expanded coordination spheres, offer the possibility of overcoming limitations inherent to platinum(II) drugs. In this review, novel strategies of targeting and killing cancer cells using platinum(IV) constructs are discussed. These approaches exploit the unique electrochemical characteristics and structural attributes of platinum(IV) complexes as a means of developing anticancer prodrugs that can target and selectively destroy cancer cells. Anticancer platinum(IV) prodrugs represent promising new strategies as targeted chemotherapeutic agents in the ongoing battle against cancer. © 2011 Bentham Science Publishers.|
|Source Title:||Current Topics in Medicinal Chemistry|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Dec 9, 2018
checked on Oct 20, 2018
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.