Please use this identifier to cite or link to this item:
https://doi.org/10.1071/CH09153
DC Field | Value | |
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dc.title | Novel orthogonal synthesis of a tagged combinatorial triazine library via grignard reaction | |
dc.contributor.author | Lee, J.W. | |
dc.contributor.author | Bork, J.T. | |
dc.contributor.author | Ha, H.-H. | |
dc.contributor.author | Samanta, A. | |
dc.contributor.author | Chang, Y.-T. | |
dc.date.accessioned | 2014-06-23T05:55:30Z | |
dc.date.available | 2014-06-23T05:55:30Z | |
dc.date.issued | 2009 | |
dc.identifier.citation | Lee, J.W., Bork, J.T., Ha, H.-H., Samanta, A., Chang, Y.-T. (2009). Novel orthogonal synthesis of a tagged combinatorial triazine library via grignard reaction. Australian Journal of Chemistry 62 (9) : 1000-1006. ScholarBank@NUS Repository. https://doi.org/10.1071/CH09153 | |
dc.identifier.issn | 00049425 | |
dc.identifier.uri | http://scholarbank.nus.edu.sg/handle/10635/77472 | |
dc.description.abstract | To expand the diversity of 1,3,5-triazine libraries to aryl and alkyl functionalities through the CC bond, we employed a novel orthogonal synthesis via Grignard monoalkylation or monoarylation of cyanuric chloride in solution to prepare aryl- or alkyl-substituted triazine building blocks. These aryl- or alkyl-substituted triazine building blocks were captured by a resin-bound amine, followed by amination and acidic cleavage with high purity. Herein, we demonstrate a novel orthogonal synthesis of a tagged aryl- and alkyl-triazine library on solid support, utilizing building blocks prepared via Grignard reaction in solution. Through incorporation of a triethylene glycol linker at one of the alternate sites on the triazine scaffold we explored an intrinsic tagged library approach. © CSIRO 2009. | |
dc.description.uri | http://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1071/CH09153 | |
dc.source | Scopus | |
dc.type | Conference Paper | |
dc.contributor.department | CHEMISTRY | |
dc.description.doi | 10.1071/CH09153 | |
dc.description.sourcetitle | Australian Journal of Chemistry | |
dc.description.volume | 62 | |
dc.description.issue | 9 | |
dc.description.page | 1000-1006 | |
dc.description.coden | AJCHA | |
dc.identifier.isiut | 000269853200009 | |
Appears in Collections: | Staff Publications |
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