Please use this identifier to cite or link to this item: https://doi.org/10.1071/CH09153
Title: Novel orthogonal synthesis of a tagged combinatorial triazine library via grignard reaction
Authors: Lee, J.W.
Bork, J.T.
Ha, H.-H. 
Samanta, A.
Chang, Y.-T. 
Issue Date: 2009
Citation: Lee, J.W., Bork, J.T., Ha, H.-H., Samanta, A., Chang, Y.-T. (2009). Novel orthogonal synthesis of a tagged combinatorial triazine library via grignard reaction. Australian Journal of Chemistry 62 (9) : 1000-1006. ScholarBank@NUS Repository. https://doi.org/10.1071/CH09153
Abstract: To expand the diversity of 1,3,5-triazine libraries to aryl and alkyl functionalities through the CC bond, we employed a novel orthogonal synthesis via Grignard monoalkylation or monoarylation of cyanuric chloride in solution to prepare aryl- or alkyl-substituted triazine building blocks. These aryl- or alkyl-substituted triazine building blocks were captured by a resin-bound amine, followed by amination and acidic cleavage with high purity. Herein, we demonstrate a novel orthogonal synthesis of a tagged aryl- and alkyl-triazine library on solid support, utilizing building blocks prepared via Grignard reaction in solution. Through incorporation of a triethylene glycol linker at one of the alternate sites on the triazine scaffold we explored an intrinsic tagged library approach. © CSIRO 2009.
Source Title: Australian Journal of Chemistry
URI: http://scholarbank.nus.edu.sg/handle/10635/77472
ISSN: 00049425
DOI: 10.1071/CH09153
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