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|Title:||Combinatorial solid-phase synthesis of 6-aryl-1,3,5-triazines via suzuki coupling|
|Citation:||Lee, J.W., Ha, H.-H., Vendrell, M., Bork, J.T., Chang, Y.-T. (2011). Combinatorial solid-phase synthesis of 6-aryl-1,3,5-triazines via suzuki coupling. Australian Journal of Chemistry 64 (5) : 540-544. ScholarBank@NUS Repository. https://doi.org/10.1071/CH11034|
|Abstract:||A synthetic methodology to prepare collections of trisubstituted aryl 1,3,5-triazines with broad structural diversity via Suzuki coupling has been developed. We first optimized the combinatorial derivatization of the triazine core using Suzuki cross-coupling. Second, in order to further expand the methodology for the preparation of negatively charged triazines, we adapted this approach to polymer-supported amino acids and prepared aryl triazines with different charge distribution. With a collection of 160 aryl triazine derivatives in good purities and without any purification step, we proved the viability of this orthogonal scheme for the preparation of triazine libraries using amine/amino acid-captured solid supports and Suzuki cross-coupling. © CSIRO 2011.|
|Source Title:||Australian Journal of Chemistry|
|Appears in Collections:||Staff Publications|
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