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Title: Combination of liquid-phase microextraction and on-column stacking for trace analysis of amino alcohols by capillary electrophoresis
Authors: Hou, L.
Wen, X.
Tu, C.
Lee, H.K. 
Keywords: Amino alcohols
Extraction methods
Field-enhanced sample stacking
Liquid-phase microextraction
Issue Date: 6-Dec-2002
Citation: Hou, L., Wen, X., Tu, C., Lee, H.K. (2002-12-06). Combination of liquid-phase microextraction and on-column stacking for trace analysis of amino alcohols by capillary electrophoresis. Journal of Chromatography A 979 (1-2) : 163-169. ScholarBank@NUS Repository.
Abstract: We described a new method for the enrichment of basic drugs present in water samples via liquid-phase microextraction (LPME) combined with on-column stacking in capillary electrophoresis. Two steps were employed to enhance the detection sensitivity of four amino alcohols. The analytes were first extracted from aqueous sample (donor solution) that were adjusted to basic through a thin layer of 1-octanol entrapped within the pores of a polypropylene hollow fiber, and then into a 5-μl acidic acceptor solution inside the hollow fiber. The extract was then further enriched through on-column stacking in capillary electrophoresis. With this two-step enrichment procedure, the method provided 72-110-fold preconcentration of the target amino alcohols. The limits of detection were 0.08-0.5 μg/ml. Relative standard deviation (n=6) ranged between 4.3 and 6.9% for the studied drugs utilizing 2-amino-1-phenylethanol as internal standard. The extraction of amino alcohols in spiked urine samples was evaluated using the developed procedure. © 2002 Elsevier Science B.V. All rights reserved.
Source Title: Journal of Chromatography A
ISSN: 00219673
DOI: 10.1016/S0021-9673(02)01266-9
Appears in Collections:Staff Publications

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