Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/77409
Title: Calcification mitigation on glutaraldehyde-fixed biological tissue by dimethylsulfoxide
Authors: Khor, E. 
Wee, A.
Loke, W.K.
Tan, B.L.
Tee, C.F. 
Issue Date: 1996
Citation: Khor, E.,Wee, A.,Loke, W.K.,Tan, B.L.,Tee, C.F. (1996). Calcification mitigation on glutaraldehyde-fixed biological tissue by dimethylsulfoxide. Transactions of the Annual Meeting of the Society for Biomaterials in conjunction with the International Biomaterials Symposium 2 : 439-. ScholarBank@NUS Repository.
Abstract: The use of dimethylsulfoxide (DMSO) to control calcification in tissues was studied. Two groups of porcine aortic valve cusp specimens were prepared; one was treated with DMSO prior to glutaraldehyde fixation and another which was glutaraldehyde fixated prior to DMSO treatment. These specimens were subcutaneously implanted in the abdominal regions of rats, were retrieved after predetermined time periods, processed and analyzed for calcification levels. Histological and chemical analysis revealed favorable low calcium levels compared to the controls indicating the ability of DMSO to delay the onset of calcification in glutaraldehyde-fixed biological tissue.
Source Title: Transactions of the Annual Meeting of the Society for Biomaterials in conjunction with the International Biomaterials Symposium
URI: http://scholarbank.nus.edu.sg/handle/10635/77409
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