Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/77395
Title: An optimization procedure for the isocratic high-performance liquid chromatographic separations of environmental pollutants
Authors: Ong, C.P. 
Khan, M.R.
Li, S.F.Y. 
Lee, H.K. 
Issue Date: 1991
Citation: Ong, C.P.,Khan, M.R.,Li, S.F.Y.,Lee, H.K. (1991). An optimization procedure for the isocratic high-performance liquid chromatographic separations of environmental pollutants. Environmental Monitoring and Assessment 19 (1-3) : 35-46. ScholarBank@NUS Repository.
Abstract: This paper describes the use of the overlapping resolution mapping procedure to optimize the separation of priority pollutants by isocratic, reversed-phase high-performance liquid chromatography. Three classes of pollutants are considered: polycyclic aromatic hydrocarbons, substituted phenols and phthalate esters. The procedure requires only seven chromatographic runs for each set of pollutants before an optimized mobile phase composition is derived which can satisfactorily resolve all the components in the respective mixtures of pollutants. The main advantage of such a systematic scheme to optimize mobile phase compositions is an improvement in method development times compared to conventional techniques. Another benefit is that expenditures on solvents are reduced.
Source Title: Environmental Monitoring and Assessment
URI: http://scholarbank.nus.edu.sg/handle/10635/77395
ISSN: 01676369
Appears in Collections:Staff Publications

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