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|Title:||Water-Soluble Conjugated Polymers for Simultaneous Two-Photon Cell Imaging and Two-Photon Photodynamic Therapy|
Min Chan, A.C.
|Source:||Shen, X., Li, L., Min Chan, A.C., Gao, N., Yao, S.Q., Xu, Q.-H. (2013-01). Water-Soluble Conjugated Polymers for Simultaneous Two-Photon Cell Imaging and Two-Photon Photodynamic Therapy. Advanced Optical Materials 1 (1) : 92-99. ScholarBank@NUS Repository. https://doi.org/10.1002/adom.201200026|
|Abstract:||Conventional photosensitizers generally suffer from low efficiency in novel non-invasive two-photon photodynamic cancer therapy due to their small two-photon absorption cross section and they lack an imaging capability for therapy guiding due to their low fluorescence yield. Demonstrated here is the first water-soluble conjugated polymers as direct two-photon photosensitizers with dual capability of two-photon cell imaging and two-photon photodynamic therapy. By introducing a strong electron-withdrawing cyano group into the phenyl ring of the backbone, the cyano-substituted poly(fluorene-2,7-ylenevinylene-co-phenylene) (PFVCN) displays a 2.4 times higher maximum two-photon absorption cross section per repeat unit and significantly higher fluorescence quantum yield in water than the unsubstituted PFV. The large two-photon absorption cross section of PFVCN allows it to efficiently generate singlet oxygen under two-photon excitation, which is critical for two-photon photodynamic therapy. Two-photon excitation cell imaging and efficient two-photon-induced photodynamic therapy effect on cancer cells of PFVCN are successfully demonstrated. These studies provide insight in designing novel photosensitizing agents for simultaneous two-photon imaging and two-photon photodynamic therapy, which allows two-photon imaging guided therapy to fully take the unique advantages of two-photon excitation such as deep penetration and 3D selectivity. A series of water-soluble conjugated polymers with large two-photon absorption cross section are synthesized. PFVCN is found to display high fluorescence brightness and a high singlet oxygen generation capability under two-photon excitation. Its potential application as a promising agent for simultaneous two-photon imaging and two-photon photodynamic therapy are demonstrated. © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.|
|Source Title:||Advanced Optical Materials|
|Appears in Collections:||Staff Publications|
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