Please use this identifier to cite or link to this item: https://doi.org/10.1016/0142-9612(93)90193-6
Title: Trivalent metal ions in the prevention of calcification in glutaraldehyde treated biological tissues. Is there a chemical correlation?
Authors: Tan, W.M.
Loke, W.K.
Tan, B.L.
Wee, A.
Khor, E. 
Goh, K.S.
Keywords: Calcification
Glutaradehyde fixation
Trivalent metal ions
Issue Date: 1993
Citation: Tan, W.M., Loke, W.K., Tan, B.L., Wee, A., Khor, E., Goh, K.S. (1993). Trivalent metal ions in the prevention of calcification in glutaraldehyde treated biological tissues. Is there a chemical correlation?. Biomaterials 14 (13) : 1003-1007. ScholarBank@NUS Repository. https://doi.org/10.1016/0142-9612(93)90193-6
Abstract: The influence of chemical factors on trivalent metal ions in the prevention of calcification of glutaraldehyde treated biological tissue has been explored. The results indicate that the chemical link lies in the hard character of the trivalent metal ions. Metal ions with the hardest character appear to have the best chance of reacting with oxygen atoms of the phosphate groups at nucleation sites of hydroxyapatite. This disrupts the nucleation and thus prevents calcification in glutaraldehyde treated biological tissue.
Source Title: Biomaterials
URI: http://scholarbank.nus.edu.sg/handle/10635/77319
ISSN: 01429612
DOI: 10.1016/0142-9612(93)90193-6
Appears in Collections:Staff Publications

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