Please use this identifier to cite or link to this item: https://doi.org/10.1021/cc050058f
Title: Traceless solid-phase synthesis of N1,N7-disubstituted purines
Authors: Fu, H. 
Lam, Y. 
Issue Date: Sep-2005
Citation: Fu, H., Lam, Y. (2005-09). Traceless solid-phase synthesis of N1,N7-disubstituted purines. Journal of Combinatorial Chemistry 7 (5) : 734-738. ScholarBank@NUS Repository. https://doi.org/10.1021/cc050058f
Abstract: A highly regioselective and traceless solid-phase route to N1,N7-disubstituted purines has been developed. Key steps in the reaction strategy involves (i) coupling of 6-chloropurine to the REM resin (Michael addition), (ii) oxidation, (iii) N1-alkylation, (iv) quaternization, and (v) product release through Hofmann elimination. A library of 15 N1,N7-disubstituted purines was synthesized. © 2005 American Chemical Society.
Source Title: Journal of Combinatorial Chemistry
URI: http://scholarbank.nus.edu.sg/handle/10635/77303
ISSN: 15204766
DOI: 10.1021/cc050058f
Appears in Collections:Staff Publications

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