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|Title:||Traceless solid-phase synthesis of N1,N7-disubstituted purines|
|Authors:||Fu, H. |
|Source:||Fu, H., Lam, Y. (2005-09). Traceless solid-phase synthesis of N1,N7-disubstituted purines. Journal of Combinatorial Chemistry 7 (5) : 734-738. ScholarBank@NUS Repository. https://doi.org/10.1021/cc050058f|
|Abstract:||A highly regioselective and traceless solid-phase route to N1,N7-disubstituted purines has been developed. Key steps in the reaction strategy involves (i) coupling of 6-chloropurine to the REM resin (Michael addition), (ii) oxidation, (iii) N1-alkylation, (iv) quaternization, and (v) product release through Hofmann elimination. A library of 15 N1,N7-disubstituted purines was synthesized. © 2005 American Chemical Society.|
|Source Title:||Journal of Combinatorial Chemistry|
|Appears in Collections:||Staff Publications|
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