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|Title:||Traceless solid-phase synthesis of heteroannulated 1,3-oxazin-6-ones|
|Citation:||Che, J., Raghavendra, M.S., Lam, Y. (2009-05-11). Traceless solid-phase synthesis of heteroannulated 1,3-oxazin-6-ones. Journal of Combinatorial Chemistry 11 (3) : 378-384. ScholarBank@NUS Repository. https://doi.org/10.1021/cc800193r|
|Abstract:||A microwave-assisted solid-phase synthesis of heteroannulated 1,3-oxazin-6-ones has been developed. Significant rate enhancement was observed for all steps carried out under microwave irradiation, and the overall reaction time was dramatically shortened when compared to the conventional procedures. A representative set of 20 bi- and tricyclic heteroannulated 1,3-oxazin-6-ones was prepared. Key steps in the synthesis are (i) five-member heterocycle formation, (ii) acylation of amine, and (iii) ring closure to give the heteroannulated 1,3-oxazin-6-one. © 2009 American Chemical Society.|
|Source Title:||Journal of Combinatorial Chemistry|
|Appears in Collections:||Staff Publications|
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