Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.bmcl.2008.01.017
Title: Synthesis and anticancer activity studies of cyclopamine derivatives
Authors: Zhang, J.
Garrossian, M.
Gardner, D.
Garrossian, A.
Chang, Y.-T. 
Kim, Y.K. 
Chang, C.-W.T.
Keywords: Bioconjugates
Carbohydrates
Cyclopamine
Hedgehog pathway
Issue Date: 15-Feb-2008
Citation: Zhang, J., Garrossian, M., Gardner, D., Garrossian, A., Chang, Y.-T., Kim, Y.K., Chang, C.-W.T. (2008-02-15). Synthesis and anticancer activity studies of cyclopamine derivatives. Bioorganic and Medicinal Chemistry Letters 18 (4) : 1359-1363. ScholarBank@NUS Repository. https://doi.org/10.1016/j.bmcl.2008.01.017
Abstract: A diversity-oriented synthesis has been developed for facile construction of a library of carbohydrate-cyclopamine conjugates. The synthetic protocol is suitable for generating cyclopamine derivatives with various structural motifs for exploring the desired activity. From this initial library, we have observed one derivative that exhibits improved activity against lung cancer cell as compared to cyclopamine. © 2008 Elsevier Ltd. All rights reserved.
Source Title: Bioorganic and Medicinal Chemistry Letters
URI: http://scholarbank.nus.edu.sg/handle/10635/77126
ISSN: 0960894X
DOI: 10.1016/j.bmcl.2008.01.017
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

55
checked on Jun 21, 2018

WEB OF SCIENCETM
Citations

52
checked on May 9, 2018

Page view(s)

56
checked on May 25, 2018

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.