Please use this identifier to cite or link to this item: https://doi.org/10.1002/anie.201003837
Title: Stereocontrolled creation of all-carbon quaternary stereocenters by organocatalytic conjugate addition of oxindoles to vinyl sulfone
Authors: Zhu, Q.
Lu, Y. 
Keywords: Amino acids
Asymmetric synthesis
Conjugate addition
Multifunctional catalysts
Oxindoles
Issue Date: 11-Oct-2010
Source: Zhu, Q., Lu, Y. (2010-10-11). Stereocontrolled creation of all-carbon quaternary stereocenters by organocatalytic conjugate addition of oxindoles to vinyl sulfone. Angewandte Chemie - International Edition 49 (42) : 7753-7756. ScholarBank@NUS Repository. https://doi.org/10.1002/anie.201003837
Abstract: Multifunctional catalysts in operation: A novel class of trifunctional thiourea catalysts containing natural amino acid residues have been prepared (see scheme), and found to be very effective towards the asymmetric addition of 3-alkyl-oxindoles to 1,1-bis(benzenesulfonyl)ethylene. This synthetic protocol has led to the enantioselective synthesis of 3-alkyl-3-aryl-disubstituted oxindoles and indolines with an all-carbon quaternary stereogenic center. © 2010 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.
Source Title: Angewandte Chemie - International Edition
URI: http://scholarbank.nus.edu.sg/handle/10635/77051
ISSN: 14337851
DOI: 10.1002/anie.201003837
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