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https://doi.org/10.1002/anie.201003837
Title: | Stereocontrolled creation of all-carbon quaternary stereocenters by organocatalytic conjugate addition of oxindoles to vinyl sulfone | Authors: | Zhu, Q. Lu, Y. |
Keywords: | Amino acids Asymmetric synthesis Conjugate addition Multifunctional catalysts Oxindoles |
Issue Date: | 11-Oct-2010 | Citation: | Zhu, Q., Lu, Y. (2010-10-11). Stereocontrolled creation of all-carbon quaternary stereocenters by organocatalytic conjugate addition of oxindoles to vinyl sulfone. Angewandte Chemie - International Edition 49 (42) : 7753-7756. ScholarBank@NUS Repository. https://doi.org/10.1002/anie.201003837 | Abstract: | Multifunctional catalysts in operation: A novel class of trifunctional thiourea catalysts containing natural amino acid residues have been prepared (see scheme), and found to be very effective towards the asymmetric addition of 3-alkyl-oxindoles to 1,1-bis(benzenesulfonyl)ethylene. This synthetic protocol has led to the enantioselective synthesis of 3-alkyl-3-aryl-disubstituted oxindoles and indolines with an all-carbon quaternary stereogenic center. © 2010 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim. | Source Title: | Angewandte Chemie - International Edition | URI: | http://scholarbank.nus.edu.sg/handle/10635/77051 | ISSN: | 14337851 | DOI: | 10.1002/anie.201003837 |
Appears in Collections: | Staff Publications |
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