Please use this identifier to cite or link to this item: https://doi.org/10.1016/S0040-4039(00)02199-7
Title: Solid-phase combinatorial synthesis of 1,4-benzoxazin-3(4H)-one and 1,4-benzothiazin-3(4H)-one derivatives
Authors: Lee, C.L.
Chan, K.P.
Lam, Y. 
Lee, S.Y. 
Keywords: 1,4-Benzothiazin-3(4H)-one
1,4-Benzoxazin-3(4H)-one
Solid-phase synthesis
Issue Date: 5-Feb-2001
Source: Lee, C.L., Chan, K.P., Lam, Y., Lee, S.Y. (2001-02-05). Solid-phase combinatorial synthesis of 1,4-benzoxazin-3(4H)-one and 1,4-benzothiazin-3(4H)-one derivatives. Tetrahedron Letters 42 (6) : 1167-1169. ScholarBank@NUS Repository. https://doi.org/10.1016/S0040-4039(00)02199-7
Abstract: The first solid-phase synthesis of 1,4-benzothiazin-3(4H)-ones and 1,4-benzoxazin-3(4H)-ones is reported. Alkylation of the immobilized 4-hydroxy-3-nitrobenzamide (2a) and 3-nitro-4-sulfanylbenzamide (2b), followed by reduction and cyclization gave 4. Further alkylation and acylation in the presence of sodium hydride followed by TFA cleavage gave the desired 1,4-benzothiazin-3(4H)-ones and 1,4-benzoxazin-3(4H)-ones. © 2001 Elsevier Science Ltd.
Source Title: Tetrahedron Letters
URI: http://scholarbank.nus.edu.sg/handle/10635/77007
ISSN: 00404039
DOI: 10.1016/S0040-4039(00)02199-7
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