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|Title:||Solid-phase combinatorial synthesis of 1,4-benzoxazin-3(4H)-one and 1,4-benzothiazin-3(4H)-one derivatives|
|Source:||Lee, C.L., Chan, K.P., Lam, Y., Lee, S.Y. (2001-02-05). Solid-phase combinatorial synthesis of 1,4-benzoxazin-3(4H)-one and 1,4-benzothiazin-3(4H)-one derivatives. Tetrahedron Letters 42 (6) : 1167-1169. ScholarBank@NUS Repository. https://doi.org/10.1016/S0040-4039(00)02199-7|
|Abstract:||The first solid-phase synthesis of 1,4-benzothiazin-3(4H)-ones and 1,4-benzoxazin-3(4H)-ones is reported. Alkylation of the immobilized 4-hydroxy-3-nitrobenzamide (2a) and 3-nitro-4-sulfanylbenzamide (2b), followed by reduction and cyclization gave 4. Further alkylation and acylation in the presence of sodium hydride followed by TFA cleavage gave the desired 1,4-benzothiazin-3(4H)-ones and 1,4-benzoxazin-3(4H)-ones. © 2001 Elsevier Science Ltd.|
|Source Title:||Tetrahedron Letters|
|Appears in Collections:||Staff Publications|
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