Please use this identifier to cite or link to this item: https://doi.org/10.1039/b700433h
Title: Ruthenium half-sandwich complexes as protein kinase inhibitors: Derivatization of the pyridocarbazole pharmacophore ligand
Authors: Pagano, N.
Maksimoska, J.
Bregman, H.
Williams, D.S.
Webster, R.D.
Xue, F. 
Meggers, E.
Issue Date: 2007
Citation: Pagano, N., Maksimoska, J., Bregman, H., Williams, D.S., Webster, R.D., Xue, F., Meggers, E. (2007). Ruthenium half-sandwich complexes as protein kinase inhibitors: Derivatization of the pyridocarbazole pharmacophore ligand. Organic and Biomolecular Chemistry 5 (8) : 1218-1227. ScholarBank@NUS Repository. https://doi.org/10.1039/b700433h
Abstract: A general route to ruthenium pyridocarbazole half-sandwich complexes is presented and applied to the synthesis of sixteen new compounds, many of which have modulated protein kinase inhibition properties. For example, the incorporation of a fluorine into the pyridine moiety increases the binding affinity for glycogen synthase kinase 3 by almost one order of magnitude. These data are supplemented with cyclic voltammetry experiments and a protein co-crystallographic study. © The Royal Society of Chemistry.
Source Title: Organic and Biomolecular Chemistry
URI: http://scholarbank.nus.edu.sg/handle/10635/76914
ISSN: 14770520
DOI: 10.1039/b700433h
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