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|Title:||Ruthenium half-sandwich complexes as protein kinase inhibitors: Derivatization of the pyridocarbazole pharmacophore ligand|
|Citation:||Pagano, N., Maksimoska, J., Bregman, H., Williams, D.S., Webster, R.D., Xue, F., Meggers, E. (2007). Ruthenium half-sandwich complexes as protein kinase inhibitors: Derivatization of the pyridocarbazole pharmacophore ligand. Organic and Biomolecular Chemistry 5 (8) : 1218-1227. ScholarBank@NUS Repository. https://doi.org/10.1039/b700433h|
|Abstract:||A general route to ruthenium pyridocarbazole half-sandwich complexes is presented and applied to the synthesis of sixteen new compounds, many of which have modulated protein kinase inhibition properties. For example, the incorporation of a fluorine into the pyridine moiety increases the binding affinity for glycogen synthase kinase 3 by almost one order of magnitude. These data are supplemented with cyclic voltammetry experiments and a protein co-crystallographic study. © The Royal Society of Chemistry.|
|Source Title:||Organic and Biomolecular Chemistry|
|Appears in Collections:||Staff Publications|
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