Please use this identifier to cite or link to this item: https://doi.org/10.1007/BF02324824
Title: Retention prediction of substituted phenols in reversed-phase HPLC
Authors: Li, S.F.Y. 
Lee, H.K. 
Keywords: Column liquid chromatography
Retention prediction
Retention/structure relationships
Substituted phenols
Issue Date: Jun-1988
Citation: Li, S.F.Y., Lee, H.K. (1988-06). Retention prediction of substituted phenols in reversed-phase HPLC. Chromatographia 25 (6) : 515-519. ScholarBank@NUS Repository. https://doi.org/10.1007/BF02324824
Abstract: A retention prediction system (RPS) for substituted phenols in reversed-phase HPLC using a ternary mobile phase was investigated. The RPS was used to predict the retention times of the phenols, and then evaluated by comparing measured and predicted retention data. Excellent agreement between both values was obtained. In addition, the retention mechanism of the phenols was investigated by means of a correlation analysis relating the parameters of the RPS to the physicochemical properties of the phenols. The three properties investigated (partition coefficient, hydrophobic substituent constant and Hammett's constant) were used to describe quantitatively the structure-retention relationship. Significant correlating equations between these descriptors and the retention data were obtained. © 1988 Friedr. Vieweg & Sohn Verlagsgesellschaft mbH.
Source Title: Chromatographia
URI: http://scholarbank.nus.edu.sg/handle/10635/76888
ISSN: 00095893
DOI: 10.1007/BF02324824
Appears in Collections:Staff Publications

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