Please use this identifier to cite or link to this item: https://doi.org/10.1016/0142-9612(95)00317-7
Title: Prevention of prosthetic valve endocarditis by impregnation of gentamicin into surgical pledgets
Authors: Khor, E. 
Tay, L.F.
Goh, K.S.
Lee, C.N.
Keywords: Drug delivery
Endocarditis
Gentamicin
Prosthetic heart valves
Issue Date: Aug-1996
Source: Khor, E., Tay, L.F., Goh, K.S., Lee, C.N. (1996-08). Prevention of prosthetic valve endocarditis by impregnation of gentamicin into surgical pledgets. Biomaterials 17 (16) : 1631-1637. ScholarBank@NUS Repository. https://doi.org/10.1016/0142-9612(95)00317-7
Abstract: A novel drug delivery system was developed for the treatment of prosthetic valve endocarditis (PVE). The antibiotic, gentamicin, was impregnated into surgical pledgets using non-solvent coacervation of polylactic acid (PLA) as a binding/encapsulating agent. The in vitro dissolution profiles show controlled release of gentamicin for up to 36 h when PLA of molecular weight 2000 is used and up to 7 d for PLA with a molecular weight of 50,000. The results indicate potential for the localized treatment of PVE, which is cost-effective, easy to manufacture and permits dosage variability.
Source Title: Biomaterials
URI: http://scholarbank.nus.edu.sg/handle/10635/76816
ISSN: 01429612
DOI: 10.1016/0142-9612(95)00317-7
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

3
checked on Mar 21, 2018

WEB OF SCIENCETM
Citations

2
checked on Mar 21, 2018

Page view(s)

29
checked on Apr 20, 2018

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.