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|Title:||Prevention of prosthetic valve endocarditis by impregnation of gentamicin into surgical pledgets|
|Authors:||Khor, E. |
Prosthetic heart valves
|Citation:||Khor, E., Tay, L.F., Goh, K.S., Lee, C.N. (1996-08). Prevention of prosthetic valve endocarditis by impregnation of gentamicin into surgical pledgets. Biomaterials 17 (16) : 1631-1637. ScholarBank@NUS Repository. https://doi.org/10.1016/0142-9612(95)00317-7|
|Abstract:||A novel drug delivery system was developed for the treatment of prosthetic valve endocarditis (PVE). The antibiotic, gentamicin, was impregnated into surgical pledgets using non-solvent coacervation of polylactic acid (PLA) as a binding/encapsulating agent. The in vitro dissolution profiles show controlled release of gentamicin for up to 36 h when PLA of molecular weight 2000 is used and up to 7 d for PLA with a molecular weight of 50,000. The results indicate potential for the localized treatment of PVE, which is cost-effective, easy to manufacture and permits dosage variability.|
|Appears in Collections:||Staff Publications|
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