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|Title:||Preparation and application of rifamycin-capped (3-(2-O-β- cyclodextrin)-2-hydroxypropoxy)-propylsilyl-appended silica particles as chiral stationary phase for high-performance liquid chromatography|
Chiral stationary phase
High-performance liquid chromatography
|Citation:||Zhao, J., Tan, D., Chelvi, S.K.T., Yong, E.L., Lee, H.K., Gong, Y. (2010-11-15). Preparation and application of rifamycin-capped (3-(2-O-β- cyclodextrin)-2-hydroxypropoxy)-propylsilyl-appended silica particles as chiral stationary phase for high-performance liquid chromatography. Talanta 83 (1) : 286-290. ScholarBank@NUS Repository. https://doi.org/10.1016/j.talanta.2010.08.031|
|Abstract:||Rifamycin-capped (3-(2-O-β-cyclodextrin)-2-hydroxypropoxy)- propylsilyl-appended silica particles (RCD-HPS), a new type of substituted β-cyclodextrin-bonded chiral stationary phase (CSP) for high-performance liquid chromatography (HPLC), have been synthesized by the treatment of bromoacetate-substituted-(3-(2-O-β-cyclodextrin)-2-hydroxypropoxy) -propylsilyl-appended silica particles (BACD-HPS) with rifamycin SV in anhydrous acetonitrile. The stationary phase is characterized by means of elemental analysis and Fourier-transform infrared spectroscopy. This new CSP has a chiral selector with two recognition sites: rifamycin and β-cyclodextrin (β-CD). The chromatographic behavior of RCD-HPS was studied with several disubstituted benzenes and some chiral drug compounds under reversed-phase HPLC mobile phase conditions. The results show that RCD-HPS has excellent selectivity for the separation of aromatic positional isomers and enantiomers of chiral compounds due to the cooperative functioning of rifamycin and β-CD. © 2010 Elsevier B.V.|
|Appears in Collections:||Staff Publications|
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