Please use this identifier to cite or link to this item:
|Title:||Preparation and application of rifamycin-capped (3-(2-O-β- cyclodextrin)-2-hydroxypropoxy)-propylsilyl-appended silica particles as chiral stationary phase for high-performance liquid chromatography|
Chiral stationary phase
High-performance liquid chromatography
|Citation:||Zhao, J., Tan, D., Chelvi, S.K.T., Yong, E.L., Lee, H.K., Gong, Y. (2010-11-15). Preparation and application of rifamycin-capped (3-(2-O-β- cyclodextrin)-2-hydroxypropoxy)-propylsilyl-appended silica particles as chiral stationary phase for high-performance liquid chromatography. Talanta 83 (1) : 286-290. ScholarBank@NUS Repository. https://doi.org/10.1016/j.talanta.2010.08.031|
|Abstract:||Rifamycin-capped (3-(2-O-β-cyclodextrin)-2-hydroxypropoxy)- propylsilyl-appended silica particles (RCD-HPS), a new type of substituted β-cyclodextrin-bonded chiral stationary phase (CSP) for high-performance liquid chromatography (HPLC), have been synthesized by the treatment of bromoacetate-substituted-(3-(2-O-β-cyclodextrin)-2-hydroxypropoxy) -propylsilyl-appended silica particles (BACD-HPS) with rifamycin SV in anhydrous acetonitrile. The stationary phase is characterized by means of elemental analysis and Fourier-transform infrared spectroscopy. This new CSP has a chiral selector with two recognition sites: rifamycin and β-cyclodextrin (β-CD). The chromatographic behavior of RCD-HPS was studied with several disubstituted benzenes and some chiral drug compounds under reversed-phase HPLC mobile phase conditions. The results show that RCD-HPS has excellent selectivity for the separation of aromatic positional isomers and enantiomers of chiral compounds due to the cooperative functioning of rifamycin and β-CD. © 2010 Elsevier B.V.|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Jul 17, 2018
WEB OF SCIENCETM
checked on Jun 27, 2018
checked on Apr 20, 2018
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.