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|Title:||Novel cytotoxic polyprenylated xanthonoids from Garcinia gaudichaudii (Guttiferae)|
|Source:||Cao, S.-G.,Sng, V.H.L.,Wu, X.-H.,Sim, K.-Y.,Tan, B.H.K.,Pereira, J.T.,Goh, S.H. (1998-09-03). Novel cytotoxic polyprenylated xanthonoids from Garcinia gaudichaudii (Guttiferae). Tetrahedron 54 (36) : 10915-10924. ScholarBank@NUS Repository.|
|Abstract:||Cytotoxicity guided phytochemical analysis of the leaf extract of the Malaysian medicinal plant Garcinia gaudichaudii led to the isolation of 15 novel cytotoxic compounds, gaudichaudiones A - H (1, 2, 8 - 10 and 12), gaudichaudiic acids A - E (3 - 6), including the known morellic acid (7) and forbesione (11). All are mainly tetraprenylated xanthonoids but gaudichaudione H (12) is a novel bridgehead methoxylated triprenylated xanthonoid. The novel caged structures were determined by detailed NMR spectral analysis and the compounds were found to exhibit significant cytotoxicity against several cancer cell lines.|
|Appears in Collections:||Staff Publications|
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