Please use this identifier to cite or link to this item: https://doi.org/10.1055/s-0031-1289538
Title: Novel amino acid based bifunctional chiral phosphines
Authors: Wang, S.-X.
Han, X.
Zhong, F.
Wang, Y.
Lu, Y. 
Keywords: [3+2] cycloaddition
amino acids
aza-Morita-Baylis- Hillman reaction
bifunctional catalysts
chiral phosphines
Issue Date: 2011
Source: Wang, S.-X., Han, X., Zhong, F., Wang, Y., Lu, Y. (2011). Novel amino acid based bifunctional chiral phosphines. Synlett (19) : 2766-2778. ScholarBank@NUS Repository. https://doi.org/10.1055/s-0031-1289538
Abstract: As a significant complement to amino catalysts, phosphines are versatile Lewis base catalysts capable of promoting a wide range of diverse organic transformations. In particular, chiral phosphines bearing a Brønsted acid moiety have recently emerged as powerful bifunctional phosphine catalysts in asymmetric synthesis and catalysis. In this account, we document our recent efforts on the design and development of novel amino acid/dipeptide-based bifunctional chiral phosphines, and their applications in enantio-selective (aza)-Morita-Baylis-Hillman (MBH) reactions and [3+2]-cycloaddition reactions. 1 Introduction 2 Bifunctional Phosphine Catalysis 3 Novel Amino Acid Based Bifunctional Chiral Phosphines 3.1 Design of Amino Acid Derived Phosphines 3.2 Threonine Core as the Chiral Scaffold 3.3 Aza-MBH Reaction Promoted by Phosphine-Sulfonamide Catalysts 3.4 MBH Reaction Catalyzed by Phosphine-Thioureas 3.5 [3+2] Cycloadditions of Allenoates to Acrylates/Acryl-amides Promoted by Dipeptide-Derived Phosphines 3.6 [3+2] Cycloaddition of the MBH Adducts Catalyzed by Phosphine-hioureas 4 Conclusion and Outlook © Georg Thieme Verlag Stuttgart · New York.
Source Title: Synlett
URI: http://scholarbank.nus.edu.sg/handle/10635/76643
ISSN: 09365214
DOI: 10.1055/s-0031-1289538
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

147
checked on Jan 16, 2018

WEB OF SCIENCETM
Citations

146
checked on Jan 16, 2018

Page view(s)

36
checked on Jan 13, 2018

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.