Please use this identifier to cite or link to this item: https://doi.org/10.1021/ja904728v
Title: Multiplex single-nucleotide polymorphism typing by nanoparticle-coupled DNA-templated reactions
Authors: Xue, X.
Xu, W.
Wang, F. 
Liu, X. 
Issue Date: 26-Aug-2009
Citation: Xue, X., Xu, W., Wang, F., Liu, X. (2009-08-26). Multiplex single-nucleotide polymorphism typing by nanoparticle-coupled DNA-templated reactions. Journal of the American Chemical Society 131 (33) : 11668-11669. ScholarBank@NUS Repository. https://doi.org/10.1021/ja904728v
Abstract: (Figure Presented) A novel chip-based detection approach for single-nucleotide polymorphism (SNP) typing based on nanoparticle-coupled DNA-templated ligation reactions is reported. In contrast to conventional methods or recently developed techniques, this approach does not need costly instrumentation and complex stringency washing processes and offers both rapid multiplex SNP detection capability and ultrahigh sensitivity. The ability of the approach to quickly identify the precise location of the single-base mismatch may provide a time-efficient method for high-throughput multiplex SNP genotyping. © 2009 American Chemical Society.
Source Title: Journal of the American Chemical Society
URI: http://scholarbank.nus.edu.sg/handle/10635/76604
ISSN: 00027863
DOI: 10.1021/ja904728v
Appears in Collections:Staff Publications

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