Please use this identifier to cite or link to this item: https://doi.org/10.1007/s12975-010-0035-3
Title: MicroRNAs in cerebral ischemia
Authors: Lim, K.-Y.
Chua, J.-H. 
Tan, J.-R.
Swaminathan, P.
Sepramaniam, S.
Armugam, A.
Wong, P.T.-H.
Jeyaseelan, K.
Keywords: Acute phase
Biomarkers
Cerebral ischemia
Gene
MCAo
MicroRNA
Issue Date: Dec-2010
Citation: Lim, K.-Y., Chua, J.-H., Tan, J.-R., Swaminathan, P., Sepramaniam, S., Armugam, A., Wong, P.T.-H., Jeyaseelan, K. (2010-12). MicroRNAs in cerebral ischemia. Translational Stroke Research 1 (4) : 287-303. ScholarBank@NUS Repository. https://doi.org/10.1007/s12975-010-0035-3
Abstract: Pathogenesis of cerebral ischemia has so far been described in the context of proteins and the pathways that they regulate. The discovery of biomarkers has also been focussed mainly on proteins and to some extent on the mRNAs that encode them. The knowledge on the role of microRNAs in understanding the pathogenesis of cerebral ischemia is still at its infancy. In this study, using rat models subjected to middle cerebral artery occlusion, we have profiled the microRNAs at different reperfusion times (0 to 48 h) to understand the progression of cerebral ischemia. We have also attempted to correlate the expression of microRNAs to treatment with an NMDA antagonist (MK801) and to protein expression with the hope of demonstrating the potential use of microRNAs as early biomarkers of stroke. © 2010 Springer Science+Business Media, LLC.
Source Title: Translational Stroke Research
URI: http://scholarbank.nus.edu.sg/handle/10635/76499
ISSN: 18684483
DOI: 10.1007/s12975-010-0035-3
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