Please use this identifier to cite or link to this item: https://doi.org/10.1002/anie.201003257
Title: Microarray-assisted high-throughput identification of a cell-permeable small-molecule binder of 14-3-3 proteins
Authors: Wu, H. 
Ge, J.
Yao, S.Q. 
Keywords: Combinatorial chemistry
Fragment-based screening
Microarrays
Protein-protein interactions
Proteins
Issue Date: 3-Sep-2010
Citation: Wu, H., Ge, J., Yao, S.Q. (2010-09-03). Microarray-assisted high-throughput identification of a cell-permeable small-molecule binder of 14-3-3 proteins. Angewandte Chemie - International Edition 49 (37) : 6528-6532. ScholarBank@NUS Repository. https://doi.org/10.1002/anie.201003257
Abstract: The way to a 14-3-3 binder: A fragment-based combinatorial small-molecule microarray generates affinity-based fingerprints of the 14-3-3σ protein. One small molecule (see picture; in red box) that disrupts the 14-3-3/protein interaction (green/blue) has been identified. The compound is cell-permeable and possesses both in vitro and in-cell activities.© 2010 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.
Source Title: Angewandte Chemie - International Edition
URI: http://scholarbank.nus.edu.sg/handle/10635/76488
ISSN: 14337851
DOI: 10.1002/anie.201003257
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