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|Title:||Kinetics and Cellular Site of Glycolipid Loading Control the Outcome of Natural Killer T Cell Activation|
|Source:||Im, J.S., Arora, P., Bricard, G., Molano, A., Venkataswamy, M.M., Baine, I., Jerud, E.S., Goldberg, M.F., Baena, A., Yu, K.O.A., Ndonye, R.M., Howell, A.R., Yuan, W., Cresswell, P., Chang, Y.-t., Illarionov, P.A., Besra, G.S., Porcelli, S.A. (2009-06-19). Kinetics and Cellular Site of Glycolipid Loading Control the Outcome of Natural Killer T Cell Activation. Immunity 30 (6) : 888-898. ScholarBank@NUS Repository. https://doi.org/10.1016/j.immuni.2009.03.022|
|Abstract:||CD1d-restricted natural killer T cells (NKT cells) possess a wide range of effector and regulatory activities that are related to their ability to secrete both T helper 1 (Th1) cell- and Th2 cell-type cytokines. We analyzed presentation of NKT cell activating α galactosylceramide (αGalCer) analogs that give predominantly Th2 cell-type cytokine responses to determine how ligand structure controls the outcome of NKT cell activation. Using a monoclonal antibody specific for αGalCer-CD1d complexes to visualize and quantitate glycolipid presentation, we found that Th2 cell-type cytokine-biasing ligands were characterized by rapid and direct loading of cell-surface CD1d proteins. Complexes formed by association of these Th2 cell-type cytokine-biasing αGalCer analogs with CD1d showed a distinctive exclusion from ganglioside-enriched, detergent-resistant plasma membrane microdomains of antigen-presenting cells. These findings help to explain how subtle alterations in glycolipid ligand structure can control the balance of proinflammatory and anti-inflammatory activities of NKT cells. © 2009 Elsevier Inc. All rights reserved.|
|Appears in Collections:||Staff Publications|
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