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Title: Kinetics and Cellular Site of Glycolipid Loading Control the Outcome of Natural Killer T Cell Activation
Authors: Im, J.S.
Arora, P.
Bricard, G.
Molano, A.
Venkataswamy, M.M.
Baine, I.
Jerud, E.S.
Goldberg, M.F.
Baena, A.
Yu, K.O.A.
Ndonye, R.M.
Howell, A.R.
Yuan, W.
Cresswell, P.
Chang, Y.-t. 
Illarionov, P.A.
Besra, G.S.
Porcelli, S.A.
Issue Date: 19-Jun-2009
Citation: Im, J.S., Arora, P., Bricard, G., Molano, A., Venkataswamy, M.M., Baine, I., Jerud, E.S., Goldberg, M.F., Baena, A., Yu, K.O.A., Ndonye, R.M., Howell, A.R., Yuan, W., Cresswell, P., Chang, Y.-t., Illarionov, P.A., Besra, G.S., Porcelli, S.A. (2009-06-19). Kinetics and Cellular Site of Glycolipid Loading Control the Outcome of Natural Killer T Cell Activation. Immunity 30 (6) : 888-898. ScholarBank@NUS Repository.
Abstract: CD1d-restricted natural killer T cells (NKT cells) possess a wide range of effector and regulatory activities that are related to their ability to secrete both T helper 1 (Th1) cell- and Th2 cell-type cytokines. We analyzed presentation of NKT cell activating α galactosylceramide (αGalCer) analogs that give predominantly Th2 cell-type cytokine responses to determine how ligand structure controls the outcome of NKT cell activation. Using a monoclonal antibody specific for αGalCer-CD1d complexes to visualize and quantitate glycolipid presentation, we found that Th2 cell-type cytokine-biasing ligands were characterized by rapid and direct loading of cell-surface CD1d proteins. Complexes formed by association of these Th2 cell-type cytokine-biasing αGalCer analogs with CD1d showed a distinctive exclusion from ganglioside-enriched, detergent-resistant plasma membrane microdomains of antigen-presenting cells. These findings help to explain how subtle alterations in glycolipid ligand structure can control the balance of proinflammatory and anti-inflammatory activities of NKT cells. © 2009 Elsevier Inc. All rights reserved.
Source Title: Immunity
ISSN: 10747613
DOI: 10.1016/j.immuni.2009.03.022
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