Please use this identifier to cite or link to this item: https://doi.org/10.1038/srep02557
Title: Kinetic evidence of an apparent negative activation enthalpy in an organocatalytic process
Authors: Han, X.
Lee, R.
Chen, T.
Luo, J.
Lu, Y. 
Huang, K.-W. 
Issue Date: 2013
Source: Han, X., Lee, R., Chen, T., Luo, J., Lu, Y., Huang, K.-W. (2013). Kinetic evidence of an apparent negative activation enthalpy in an organocatalytic process. Scientific Reports 3 : -. ScholarBank@NUS Repository. https://doi.org/10.1038/srep02557
Abstract: A combined kinetic and computational study on our tryptophan-based bifunctional thiourea catalyzed asymmetric Mannich reactions reveals an apparent negative activation enthalpy. The formation of the pre-transition state complex has been unambiguously confirmed and these observations provide an experimental support for the formation of multiple hydrogen bonding network between the substrates and the catalyst. Such interactions allow the creation of a binding cavity, a key factor to install high enantioselectivity.
Source Title: Scientific Reports
URI: http://scholarbank.nus.edu.sg/handle/10635/76423
ISSN: 20452322
DOI: 10.1038/srep02557
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