Please use this identifier to cite or link to this item: https://doi.org/10.1002/chem.201103136
Title: Highly enantioselective assembly of functionalized tetrahydroquinolines with creation of an all-carbon quaternary center
Authors: Tan, H.R.
Ng, H.F.
Chang, J.
Wang, J. 
Keywords: asymmetric synthesis
cascade reactions
organocatalysis
tetrahydroquinolines
thioureas
Issue Date: 26-Mar-2012
Source: Tan, H.R., Ng, H.F., Chang, J., Wang, J. (2012-03-26). Highly enantioselective assembly of functionalized tetrahydroquinolines with creation of an all-carbon quaternary center. Chemistry - A European Journal 18 (13) : 3865-3870. ScholarBank@NUS Repository. https://doi.org/10.1002/chem.201103136
Abstract: A Mannich-Michael combo: An efficient and highly enantioselective cascade process by H-bonding catalysis for the synthesis of functionalized tetrahydroquinolines has been developed. An indane amine-thiourea small molecule has been discovered to catalyze this process in high yields and with good diastereomeric ratios and excellent enantioselectivities (see scheme). Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Source Title: Chemistry - A European Journal
URI: http://scholarbank.nus.edu.sg/handle/10635/76305
ISSN: 09476539
DOI: 10.1002/chem.201103136
Appears in Collections:Staff Publications

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