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Title: Functionalized xenon as a biosensor
Authors: Spence, M.M.
Rubin, S.M.
Dimitrov, I.E.
Ruiz, E.J.
Wemmer, D.E.
Pines, A.
Yao, S.Q. 
Tian, F.
Schultz, P.G.
Issue Date: 11-Sep-2001
Citation: Spence, M.M., Rubin, S.M., Dimitrov, I.E., Ruiz, E.J., Wemmer, D.E., Pines, A., Yao, S.Q., Tian, F., Schultz, P.G. (2001-09-11). Functionalized xenon as a biosensor. Proceedings of the National Academy of Sciences of the United States of America 98 (19) : 10654-10657. ScholarBank@NUS Repository.
Abstract: The detection of biological molecules and their interactions is a significant component of modern biomedical research. In current biosensor technologies, simultaneous detection is limited to a small number of analytes by the spectral overlap of their signals. We have developed an NMR-based xenon biosensor that capitalizes on the enhanced signal-to-noise, spectral simplicity, and chemical-shift sensitivity of laser-polarized xenon to detect specific biomolecules at the level of tens of nanomoles. We present results using xenon "functionalized" by a biotin-modified supramolecular cage to detect biotin-avidin binding. This biosensor methodology can be extended to a multiplexing assay for multiple analytes.
Source Title: Proceedings of the National Academy of Sciences of the United States of America
ISSN: 00278424
DOI: 10.1073/pnas.191368398
Appears in Collections:Staff Publications

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