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|Title:||Functionalized xenon as a biosensor|
|Citation:||Spence, M.M., Rubin, S.M., Dimitrov, I.E., Ruiz, E.J., Wemmer, D.E., Pines, A., Yao, S.Q., Tian, F., Schultz, P.G. (2001-09-11). Functionalized xenon as a biosensor. Proceedings of the National Academy of Sciences of the United States of America 98 (19) : 10654-10657. ScholarBank@NUS Repository. https://doi.org/10.1073/pnas.191368398|
|Abstract:||The detection of biological molecules and their interactions is a significant component of modern biomedical research. In current biosensor technologies, simultaneous detection is limited to a small number of analytes by the spectral overlap of their signals. We have developed an NMR-based xenon biosensor that capitalizes on the enhanced signal-to-noise, spectral simplicity, and chemical-shift sensitivity of laser-polarized xenon to detect specific biomolecules at the level of tens of nanomoles. We present results using xenon "functionalized" by a biotin-modified supramolecular cage to detect biotin-avidin binding. This biosensor methodology can be extended to a multiplexing assay for multiple analytes.|
|Source Title:||Proceedings of the National Academy of Sciences of the United States of America|
|Appears in Collections:||Staff Publications|
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