Please use this identifier to cite or link to this item:
https://doi.org/10.1002/anie.200903747
DC Field | Value | |
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dc.title | Functional profiling, identification, and inhibition of plasmepsins in intraerythrocytic malaria parasites | |
dc.contributor.author | Liu, K. | |
dc.contributor.author | Shi, H. | |
dc.contributor.author | Xiao, H. | |
dc.contributor.author | Chong, A.G.L. | |
dc.contributor.author | Bi, X. | |
dc.contributor.author | Chang, Y.-T. | |
dc.contributor.author | Tan, K.S.W. | |
dc.contributor.author | Yada, R.Y. | |
dc.contributor.author | Yao, S.Q. | |
dc.date.accessioned | 2014-06-23T05:40:09Z | |
dc.date.available | 2014-06-23T05:40:09Z | |
dc.date.issued | 2009-10-19 | |
dc.identifier.citation | Liu, K., Shi, H., Xiao, H., Chong, A.G.L., Bi, X., Chang, Y.-T., Tan, K.S.W., Yada, R.Y., Yao, S.Q. (2009-10-19). Functional profiling, identification, and inhibition of plasmepsins in intraerythrocytic malaria parasites. Angewandte Chemie - International Edition 48 (44) : 8293-8297. ScholarBank@NUS Repository. https://doi.org/10.1002/anie.200903747 | |
dc.identifier.issn | 14337851 | |
dc.identifier.uri | http://scholarbank.nus.edu.sg/handle/10635/76228 | |
dc.description.abstract | Profile and eliminate! Plasmepsins (PMs), aspartic proteases required for malariaparasite growth, are promising antimalarial targets. The in situ screening of PMs with probes formed from β-hydroxyazides 1 and alkynes with a photo-cross-linking unit and a tetraethylrhodamine reporter led to the identification of the smallmolecule inhibitor 2, which inhibits all fourfood-vacuole PMs and showed potent antimalarial activity in red-blood-cell cultures. © 2009 Wiley-VCH Verlag GmbH S. Co. KCaA. | |
dc.description.uri | http://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1002/anie.200903747 | |
dc.source | Scopus | |
dc.subject | Activity-based profiling | |
dc.subject | Affinity-based profiling | |
dc.subject | Chemical proteomics | |
dc.subject | Click chemistry | |
dc.subject | Malaria | |
dc.type | Article | |
dc.contributor.department | BIOLOGICAL SCIENCES | |
dc.contributor.department | CHEMISTRY | |
dc.description.doi | 10.1002/anie.200903747 | |
dc.description.sourcetitle | Angewandte Chemie - International Edition | |
dc.description.volume | 48 | |
dc.description.issue | 44 | |
dc.description.page | 8293-8297 | |
dc.description.coden | ACIEA | |
dc.identifier.isiut | 000271302900021 | |
Appears in Collections: | Staff Publications |
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