Please use this identifier to cite or link to this item: https://doi.org/10.1002/anie.200903747
Title: Functional profiling, identification, and inhibition of plasmepsins in intraerythrocytic malaria parasites
Authors: Liu, K.
Shi, H.
Xiao, H.
Chong, A.G.L.
Bi, X. 
Chang, Y.-T. 
Tan, K.S.W.
Yada, R.Y.
Yao, S.Q. 
Keywords: Activity-based profiling
Affinity-based profiling
Chemical proteomics
Click chemistry
Malaria
Issue Date: 19-Oct-2009
Source: Liu, K., Shi, H., Xiao, H., Chong, A.G.L., Bi, X., Chang, Y.-T., Tan, K.S.W., Yada, R.Y., Yao, S.Q. (2009-10-19). Functional profiling, identification, and inhibition of plasmepsins in intraerythrocytic malaria parasites. Angewandte Chemie - International Edition 48 (44) : 8293-8297. ScholarBank@NUS Repository. https://doi.org/10.1002/anie.200903747
Abstract: Profile and eliminate! Plasmepsins (PMs), aspartic proteases required for malariaparasite growth, are promising antimalarial targets. The in situ screening of PMs with probes formed from β-hydroxyazides 1 and alkynes with a photo-cross-linking unit and a tetraethylrhodamine reporter led to the identification of the smallmolecule inhibitor 2, which inhibits all fourfood-vacuole PMs and showed potent antimalarial activity in red-blood-cell cultures. © 2009 Wiley-VCH Verlag GmbH S. Co. KCaA.
Source Title: Angewandte Chemie - International Edition
URI: http://scholarbank.nus.edu.sg/handle/10635/76228
ISSN: 14337851
DOI: 10.1002/anie.200903747
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