Enantioselective [3 + 2] cycloaddition of allenes to acrylates catalyzed by dipeptide-derived phosphines: Facile creation of functionalized cyclopentenes containing quaternary stereogenic centers

Please use this identifier to cite or link to this item: https://doi.org/10.1021/ja1106282

Title:	Enantioselective [3 + 2] cycloaddition of allenes to acrylates catalyzed by dipeptide-derived phosphines: Facile creation of functionalized cyclopentenes containing quaternary stereogenic centers
Authors:	Han, X. Wang, Y. Zhong, F. Lu, Y.
Issue Date:	16-Feb-2011
Citation:	Han, X., Wang, Y., Zhong, F., Lu, Y. (2011-02-16). Enantioselective [3 + 2] cycloaddition of allenes to acrylates catalyzed by dipeptide-derived phosphines: Facile creation of functionalized cyclopentenes containing quaternary stereogenic centers. Journal of the American Chemical Society 133 (6) : 1726-1729. ScholarBank@NUS Repository. https://doi.org/10.1021/ja1106282
Abstract:	A new family of dipeptide-based chiral phosphines was designed and prepared. d-Thr-l-tert-Leu-derived catalyst 4c promoted [3 + 2] cycloaddition of allenoates to α-substituted acrylates in a regiospecific and stereoselective manner, furnishing functionalized cyclopentenes with quaternary stereogenic centers in high yields and with excellent enantioselectivities. © 2011 American Chemical Society.
Source Title:	Journal of the American Chemical Society
URI:	http://scholarbank.nus.edu.sg/handle/10635/76095
ISSN:	00027863
DOI:	10.1021/ja1106282
Appears in Collections:	Staff Publications

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