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|Title:||Dynamic monitoring of newly synthesized proteomes: Up-regulation of myristoylated protein kinase a during butyric acid induced apoptosis|
|Citation:||Liu, K., Yang, P.-Y., Na, Z., Yao, S.Q. (2011-07-18). Dynamic monitoring of newly synthesized proteomes: Up-regulation of myristoylated protein kinase a during butyric acid induced apoptosis. Angewandte Chemie - International Edition 50 (30) : 6776-6781. ScholarBank@NUS Repository. https://doi.org/10.1002/anie.201102542|
|Abstract:||Doubly charged: A double metabolic incorporation approach capable of proteome-wide profiling of post-translational modification dynamics on newly synthesized proteins has been developed (see scheme; blue box: methionine surrogate, orange diamond: PTM probe). This strategy reveals for the first time that up-regulation of myristoylated PKA protein is necessary for the occurrence of butyric acid induced apoptosis in Jurkat cells. Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.|
|Source Title:||Angewandte Chemie - International Edition|
|Appears in Collections:||Staff Publications|
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