Please use this identifier to cite or link to this item: https://doi.org/10.1002/anie.201102542
Title: Dynamic monitoring of newly synthesized proteomes: Up-regulation of myristoylated protein kinase a during butyric acid induced apoptosis
Authors: Liu, K.
Yang, P.-Y.
Na, Z.
Yao, S.Q. 
Keywords: apoptosis
click chemistry
metabolic incorporation
post-translational modification
proteins
Issue Date: 18-Jul-2011
Citation: Liu, K., Yang, P.-Y., Na, Z., Yao, S.Q. (2011-07-18). Dynamic monitoring of newly synthesized proteomes: Up-regulation of myristoylated protein kinase a during butyric acid induced apoptosis. Angewandte Chemie - International Edition 50 (30) : 6776-6781. ScholarBank@NUS Repository. https://doi.org/10.1002/anie.201102542
Abstract: Doubly charged: A double metabolic incorporation approach capable of proteome-wide profiling of post-translational modification dynamics on newly synthesized proteins has been developed (see scheme; blue box: methionine surrogate, orange diamond: PTM probe). This strategy reveals for the first time that up-regulation of myristoylated PKA protein is necessary for the occurrence of butyric acid induced apoptosis in Jurkat cells. Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Source Title: Angewandte Chemie - International Edition
URI: http://scholarbank.nus.edu.sg/handle/10635/75996
ISSN: 14337851
DOI: 10.1002/anie.201102542
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

9
checked on May 21, 2018

WEB OF SCIENCETM
Citations

8
checked on Apr 30, 2018

Page view(s)

47
checked on May 18, 2018

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.