Please use this identifier to cite or link to this item: https://doi.org/10.1007/s10404-010-0639-7
Title: Droplet microfluidic preparation of au nanoparticles-coated chitosan microbeads for flow-through surface-enhanced Raman scattering detection
Authors: Wang, W.
Yang, C.
Cui, X.Q.
Bao, Q.L. 
Li, C.M.
Keywords: Lab-on-a-chip
Microbead
Microdroplet
Microfluidics
Nanoparticle synthesis
SERS
Issue Date: Dec-2010
Citation: Wang, W., Yang, C., Cui, X.Q., Bao, Q.L., Li, C.M. (2010-12). Droplet microfluidic preparation of au nanoparticles-coated chitosan microbeads for flow-through surface-enhanced Raman scattering detection. Microfluidics and Nanofluidics 9 (6) : 1175-1183. ScholarBank@NUS Repository. https://doi.org/10.1007/s10404-010-0639-7
Abstract: An integrated microfluidic device was fabricated to enable on-chip droplet forming, trapping, fusing, shrinking, reaction and producing functional microbeads for a flow-through single bead-based molecule detection. Dielectrophoresis (DEP) force was used to transport target polymer droplets into different predefined microwells, where the droplets were fused through electrocoalescence to form a new one with a desired diameter. In a continuous water loss process with water diffusion to oil phase, the polymer droplet was shrunken and solidified to form a polymer microbead. For a demonstration, Au nanoparticles-coated chitosan microbeads were in situ fabricated through droplet trapping, fusion and shrinking, followed by synthesis of Au nanoparticles on the microbead surface via a photoreduction process. The produced Au nanoparticle/chitosan microbead embedded in the microwell resulted in a highly sensitive, flow-through surface-enhanced Raman scattering (SERS) detection of Rhodamine 6G (R6G). This work successfully demonstrates an integrated droplet based lab-on-a chip and its application to fabricate an extremely high-throughput single bead based detection platform. © 2010 Springer-Verlag.
Source Title: Microfluidics and Nanofluidics
URI: http://scholarbank.nus.edu.sg/handle/10635/75985
ISSN: 16134982
DOI: 10.1007/s10404-010-0639-7
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