Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.bioorg.2007.12.004
Title: Divergent syntheses of all stereoisomers of phytosphingosine and their use in the construction of a ceramide library
Authors: Park, J.-J.
Lee, J.H.
Li, Q.
Diaz, K.
Chang, Y.-T. 
Chung, S.-K.
Keywords: Apoptosis
Ceramide
Inflammatory response
Library
Phytosphingosine
Solid phase acylating reagent
Issue Date: Oct-2008
Source: Park, J.-J., Lee, J.H., Li, Q., Diaz, K., Chang, Y.-T., Chung, S.-K. (2008-10). Divergent syntheses of all stereoisomers of phytosphingosine and their use in the construction of a ceramide library. Bioorganic Chemistry 36 (5) : 220-228. ScholarBank@NUS Repository. https://doi.org/10.1016/j.bioorg.2007.12.004
Abstract: Sphingolipids such as ceramide and sphingosine-1-phosphate have recently attracted intense research interests because of their functional roles as signaling molecules in many important physiological processes, such as growth arrest, apoptosis, and inflammatory responses, and cell proliferation, vascular maturation and trafficking of lymphocytes. The well-defined modular structures of ceramides and related glycosylceramides are ideally amenable to library formation for medicinal chemistry investigation. We have developed divergent synthetic routes to all eight phytosphingosine stereoisomers and then proceeded to prepare phytosphingosine-based ceramide library composed of more than 500 compounds. © 2008 Elsevier Inc. All rights reserved.
Source Title: Bioorganic Chemistry
URI: http://scholarbank.nus.edu.sg/handle/10635/75979
ISSN: 00452068
DOI: 10.1016/j.bioorg.2007.12.004
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