Please use this identifier to cite or link to this item: https://doi.org/10.1039/b701579h
Title: Direct asymmetric three-component organocatalytic anti-selective Mannich reactions in a purely aqueous system
Authors: Cheng, L.
Wu, X. 
Lu, Y. 
Issue Date: 2007
Citation: Cheng, L., Wu, X., Lu, Y. (2007). Direct asymmetric three-component organocatalytic anti-selective Mannich reactions in a purely aqueous system. Organic and Biomolecular Chemistry 5 (7) : 1018-1020. ScholarBank@NUS Repository. https://doi.org/10.1039/b701579h
Abstract: The direct three-component Mannich reactions of O-benzyl hydroxyacetone with p-anisidine and aromatic or aliphatic aldehydes in the presence of an l-threonine-derived catalyst afforded anti-1,2-amino alcohols in good-to-excellent yields and with enantioselectivities of up to 97%. This study is the first demonstration that direct three-component Mannich reactions can be promoted by a primary amino acid in water. This journal is © The Royal Society of Chemistry.
Source Title: Organic and Biomolecular Chemistry
URI: http://scholarbank.nus.edu.sg/handle/10635/75952
ISSN: 14770520
DOI: 10.1039/b701579h
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