Please use this identifier to cite or link to this item: https://doi.org/10.1039/c2cc31439h
Title: Direct asymmetric Mannich reaction of phthalides: Facile access to chiral substituted isoquinolines and isoquinolinones
Authors: Luo, J.
Wang, H.
Zhong, F.
Kwiatkowski, J.
Xu, L.-W.
Lu, Y. 
Issue Date: 16-May-2012
Citation: Luo, J., Wang, H., Zhong, F., Kwiatkowski, J., Xu, L.-W., Lu, Y. (2012-05-16). Direct asymmetric Mannich reaction of phthalides: Facile access to chiral substituted isoquinolines and isoquinolinones. Chemical Communications 48 (39) : 4707-4709. ScholarBank@NUS Repository. https://doi.org/10.1039/c2cc31439h
Abstract: The first Mannich reaction employing phthalides using a quinidine-based multifunctional catalyst has been developed. The reported method led to the synthesis of 3,3-disubstituted phthalide derivatives in excellent yields, with good diastereo- and enantioselectivities. Convenient synthesis of chiral isoquinolinones and isoquinolines has also been demonstrated. © 2012 The Royal Society of Chemistry.
Source Title: Chemical Communications
URI: http://scholarbank.nus.edu.sg/handle/10635/75950
ISSN: 13597345
DOI: 10.1039/c2cc31439h
Appears in Collections:Staff Publications

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