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|Title:||Direct asymmetric Mannich reaction of phthalides: Facile access to chiral substituted isoquinolines and isoquinolinones|
|Citation:||Luo, J., Wang, H., Zhong, F., Kwiatkowski, J., Xu, L.-W., Lu, Y. (2012-05-16). Direct asymmetric Mannich reaction of phthalides: Facile access to chiral substituted isoquinolines and isoquinolinones. Chemical Communications 48 (39) : 4707-4709. ScholarBank@NUS Repository. https://doi.org/10.1039/c2cc31439h|
|Abstract:||The first Mannich reaction employing phthalides using a quinidine-based multifunctional catalyst has been developed. The reported method led to the synthesis of 3,3-disubstituted phthalide derivatives in excellent yields, with good diastereo- and enantioselectivities. Convenient synthesis of chiral isoquinolinones and isoquinolines has also been demonstrated. © 2012 The Royal Society of Chemistry.|
|Source Title:||Chemical Communications|
|Appears in Collections:||Staff Publications|
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