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Please use this identifier to cite or link to this item: https://doi.org/10.1002/anie.201300683
DC FieldValue
dc.titleDesign and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling
dc.contributor.authorLi, Z.
dc.contributor.authorHao, P.
dc.contributor.authorLi, L.
dc.contributor.authorTan, C.Y.J.
dc.contributor.authorCheng, X.
dc.contributor.authorChen, G.Y.J.
dc.contributor.authorSze, S.K.
dc.contributor.authorShen, H.-M.
dc.contributor.authorYao, S.Q.
dc.date.accessioned2014-06-23T05:35:39Z
dc.date.available2014-06-23T05:35:39Z
dc.date.issued2013-08-12
dc.identifier.citationLi, Z., Hao, P., Li, L., Tan, C.Y.J., Cheng, X., Chen, G.Y.J., Sze, S.K., Shen, H.-M., Yao, S.Q. (2013-08-12). Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angewandte Chemie - International Edition 52 (33) : 8551-8556. ScholarBank@NUS Repository. https://doi.org/10.1002/anie.201300683
dc.identifier.issn14337851
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/75868
dc.description.abstractLess is more: A minimalist "clickable" photo-crosslinker (see scheme) was incorporated with numerous small-molecule kinase inhibitors. The resulting probes were used for both in vitro (cell lysates) and in situ (live cells) proteome profiling, for large-scale identification of their potential cellular kinase targets and shows improved outcomes over previous probes. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1002/anie.201300683
dc.sourceScopus
dc.subjectaffinity-based probes
dc.subjectfluorescent probes
dc.subjectkinases
dc.subjectphoto-crosslinking
dc.subjectproteomics
dc.typeArticle
dc.contributor.departmentCHEMISTRY
dc.contributor.departmentSAW SWEE HOCK SCHOOL OF PUBLIC HEALTH
dc.description.doi10.1002/anie.201300683
dc.description.sourcetitleAngewandte Chemie - International Edition
dc.description.volume52
dc.description.issue33
dc.description.page8551-8556
dc.description.codenACIEF
dc.identifier.isiut000322835700013
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