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|Title:||Cytotoxicity of triorganophosphinegold(I) n-mercaptobenzoates, n = 2, 3 and 4|
|Authors:||De Vos, D.|
|Source:||De Vos, D.,Smyth, D.R.,Tiekink, E.R.T. (2002). Cytotoxicity of triorganophosphinegold(I) n-mercaptobenzoates, n = 2, 3 and 4. Metal-Based Drugs 8 (6) : 303-306. ScholarBank@NUS Repository.|
|Abstract:||The results of cytotoxicity trials against a panel of seven human cell lines for a series of triorganophosphinegold(I) 3- and 4-mercaptobenzoates are reported. While the new compounds show moderate to high toxicity, their potencies are inferior to those reported previously for their isomeric 2-mercaptobenzoate derivatives. The results therefore suggest a structure-activity relationship in that the 2-isomeric species are more active, particularly against the non-small cell lung cancer and renal cancer cell lines, results that may indicate some selectivity in their cytotoxic profile.|
|Source Title:||Metal-Based Drugs|
|Appears in Collections:||Staff Publications|
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