Please use this identifier to cite or link to this item: https://doi.org/10.1016/S0162-0134(99)00131-2
Title: Cytotoxicity of salicylaldehyde benzoylhydrazone analogs and their transition metal complexes: Quantitative structure-activity relationships
Authors: Ainscough, E.W.
Brodie, A.M.
Denny, W.A.
Finlay, G.J.
Gothe, S.A.
Ranford, J.D. 
Keywords: Cytotoxicity
Salicylaldehyde benzoylhydrazone
Structure-activity relationships
Issue Date: 30-Nov-1999
Source: Ainscough, E.W., Brodie, A.M., Denny, W.A., Finlay, G.J., Gothe, S.A., Ranford, J.D. (1999-11-30). Cytotoxicity of salicylaldehyde benzoylhydrazone analogs and their transition metal complexes: Quantitative structure-activity relationships. Journal of Inorganic Biochemistry 77 (3-4) : 125-133. ScholarBank@NUS Repository. https://doi.org/10.1016/S0162-0134(99)00131-2
Abstract: A series of salicylaldehyde benzoylhydrazone derivatives, their copper(II) complexes and a range of transition metal complexes of the unsubstituted ligand has been synthesized and evaluated for cytotoxicity against a human adenocarcinoma cell line. A QSAR analysis revealed ligand cytotoxicity is strongly correlated with electronic and transport factors and can be modeled by treating each 'half' of the molecule as an isolated unit. Activity increases when substituents in the benzoyl ring were electron withdrawing whereas, for the salicylaldehyde ring, electron donation was required. The cytotoxicity of the Cu(II) complexes was greater than, and paralleled the ligands. Activity for the transition metal complexes of the unsubstituted ligand mirrored charge density on the metal.
Source Title: Journal of Inorganic Biochemistry
URI: http://scholarbank.nus.edu.sg/handle/10635/75851
ISSN: 01620134
DOI: 10.1016/S0162-0134(99)00131-2
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

76
checked on Feb 14, 2018

WEB OF SCIENCETM
Citations

69
checked on Jan 15, 2018

Page view(s)

28
checked on Feb 18, 2018

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.