Please use this identifier to cite or link to this item: https://doi.org/10.3390/molecules18022255
Title: Characterization of proanthocyanidins in stems of Polygonum multiflorum thunb as strong starch hydrolase inhibitors
Authors: Wang, H.
Song, L.
Feng, S.
Liu, Y.
Zuo, G.
Lai, F.
He, G.
Chen, M.
Huang, D. 
Keywords: α-amylase; (epi)catechin
P. multiflorum
Proanthocyanidins
Issue Date: Feb-2013
Citation: Wang, H., Song, L., Feng, S., Liu, Y., Zuo, G., Lai, F., He, G., Chen, M., Huang, D. (2013-02). Characterization of proanthocyanidins in stems of Polygonum multiflorum thunb as strong starch hydrolase inhibitors. Molecules 18 (2) : 2255-2265. ScholarBank@NUS Repository. https://doi.org/10.3390/molecules18022255
Abstract: Characterzation of polyphenolic compounds in the stems of P. multiflorum was conducted using HPLC, high resolution LC-MS and LC-MSn. Proanthocyanidins in particular were isolated in 4.8% yield using solvent extraction followed by Sephadex LH-20 fractionation. HPLC analysis using a diol column revealed oligomers (from dimer to nonamer) as minor components, with (epi)catechin monomeric units predominating, and oligomers with higher degree of polymerization being dominant. Thiolysis treatment of the proanthocyanidins using mercaptoacetic acid produced thioether derivatives of (epi)catechin as the major product and a mean value of the degree of polymerization of 32.6 was estimated from the ratio of terminal and extension units of the (epi)catechin. The isolated proanthocyanidins were shown to strongly inhibit α-amylase with an acarbose equivalence (AE) value of 1,954.7 μmol AE/g and inhibit α-glucosidase with an AE value of 211.1 μmol AE/g. © 2013 by the authors.
Source Title: Molecules
URI: http://scholarbank.nus.edu.sg/handle/10635/75723
ISSN: 14203049
DOI: 10.3390/molecules18022255
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