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https://doi.org/10.1016/j.bmcl.2008.04.076
| Title: | C3-Spacer-containing circular oligonucleotides as inhibitors of human topoisomerase I |
| Authors: | Wang, Y. Ng, M.T.T. Zhou, T. Li, X. Tan, C.H. Li, T. |
| Keywords: | Circular oligonucleotide Enzyme inhibitor Human topoisomerase I |
| Issue Date: | 15-Jun-2008 |
| Citation: | Wang, Y., Ng, M.T.T., Zhou, T., Li, X., Tan, C.H., Li, T. (2008-06-15). C3-Spacer-containing circular oligonucleotides as inhibitors of human topoisomerase I. Bioorganic and Medicinal Chemistry Letters 18 (12) : 3597-3602. ScholarBank@NUS Repository. https://doi.org/10.1016/j.bmcl.2008.04.076 |
| Abstract: | Some dumbbell-shaped circular oligonucleotides containing internal C3-spacers and Topo I-binding sites were designed and synthesized which displayed high inhibitory efficiency on the activity of human Topo I as well as resisted the degradation by some DNA repair enzymes. © 2008 Elsevier Ltd. All rights reserved. |
| Source Title: | Bioorganic and Medicinal Chemistry Letters |
| URI: | http://scholarbank.nus.edu.sg/handle/10635/75686 |
| ISSN: | 0960894X |
| DOI: | 10.1016/j.bmcl.2008.04.076 |
| Appears in Collections: | Staff Publications |
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