Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.febslet.2008.01.043
Title: Antimicrobial properties of avian eggshell-specific C-type lectin-like proteins
Authors: Wellman-Labadie, O.
Lakshminarayanan, R. 
Hincke, M.T.
Keywords: Antibacterial
Antibiotics
Avian eggshell
Bacterial polysaccharides
C-type lectin
Issue Date: 5-Mar-2008
Source: Wellman-Labadie, O., Lakshminarayanan, R., Hincke, M.T. (2008-03-05). Antimicrobial properties of avian eggshell-specific C-type lectin-like proteins. FEBS Letters 582 (5) : 699-704. ScholarBank@NUS Repository. https://doi.org/10.1016/j.febslet.2008.01.043
Abstract: C-type lectin-like proteins are major components of the calcified eggshell of multiple avian species. In this study, two representative avian C-type lectin-like proteins, ovocleidin-17 and ansocalcin, were purified from decalcified chicken and goose eggshell protein extracts and investigated for carbohydrate binding activity as well as antimicrobial activity. Purified ovocleidin-17 and ansocalcin were found to bind bacterial polysaccharides, and were bactericidal against Bacillus subtilis, Staphylococcus aureus and Pseudomona aeruginosa. Bactericidal activity was found to be enhanced in the presence of calcium but was not dependent on its presence. The results suggest that avian C-type lectin-like proteins may play an important antimicrobial role in defence of the avian embryo. © 2008 Federation of European Biochemical Societies.
Source Title: FEBS Letters
URI: http://scholarbank.nus.edu.sg/handle/10635/75585
ISSN: 00145793
DOI: 10.1016/j.febslet.2008.01.043
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